The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it appears based on both preclinical and clinical studies that bdnf isn't just one of the ways in which ketamine can invoke neuroplasticity and these improvements in mood it may actually be required it may be the central process to all of that
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
ketamine induced release of bdnf is one of the core mechanisms by which ketamine can relieve depression now there are several lines of evidence to support what I just said about bdnf in the context of ketamine first of all in mice that lack bdnf they have no bdnf they can't make bdnf because they don't have the gene for bdnf we call those bdnf knockout mice in those mice if you give them ketamine and you put them into that learned helplessness task that we talked about a bit earlier where you put them into water and see how long they swim normally ketamine would allow a mouse to swim longer to fight for its life longer well it no longer does that in a bdnf knockout Mouse
one of the key ones to understand is the thing I mentioned at the beginning of today's episode bdnf which stands for brain derived neutrophic Factor