Andrew Huberman· PhD
all of the changes in neural circuits that we're talking about that can come about from taking a drug well those changes don't actually do a whole lot unless those circuits are reinforced by particular behaviors
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
all of the changes in neural circuits that we're talking about that can come about from taking a drug well those changes don't actually do a whole lot unless those circuits are reinforced by particular behaviors
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if somebody takes ketamine and they are reducing the amount of output from this disappointment circuit this habenula to the reward circuitry of the brain and they do engage in behaviors such as seeking out work that stimulates them seeking out social engagement taking good care of their body their mental health their physical health Etc well those circuits are not designed to respond to ketamine they are designed to respond to particular patterns of thinking and behavior