Rhonda Patrick· PhD
In people with major depressive disorder, a single session of raising core body temperature by 2.6–3.7℉ (a mild "fever-range" heat stimulus) produced an antidepressant effect that lasted 6–8 weeks.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
In people with major depressive disorder, a single session of raising core body temperature by 2.6–3.7℉ (a mild "fever-range" heat stimulus) produced an antidepressant effect that lasted 6–8 weeks.
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in fact in fact there was a friend of mine published a randomized control trial where he elevated people that had major depression elevated their core body temperature about one or two degrees and just one exposure to that had an antidepressant effect that lasted weeks compared to people that got the Sham control
what they found was that the decrease in body temperature was correlated with a decrease in depression.