High-dose omega-3 supplementation may improve depressive and some manic symptoms in bipolar disorder.

“Here's the major takeaway, supplementing with high dose omega-3s does seem to be beneficial for a good number of people with bipolar disorder. However, again, I want to highlight, however, it should not be viewed as the only treatment approach for bipolar disorder. ... However, omega-3 supplementation does seem to improve or reduce the depressive symptoms in the major depressive episodes of bipolar. And there are a couple studies, and we'll link to these in the show notes as well, that show that it may even improve some of the manic episodes as well, meaning it reduces some of the manic symptoms.”