Tricyclic antidepressants and MAO inhibitors can relieve depression symptoms but have side effects like dry mouth, low libido, sleep issues, appetite changes, and weight gain.

“And frankly, they do quite a good job of relieving some, if not all of the symptoms of major depression. However, they carry with the many side effects. Some of those side effects are side effects related to blood pressure itself, by increasing noradrenaline, norepinephrine as it's called, you raise blood pressure. That can be dangerous, that can be uncomfortable. But they also have a lot of other side effects. The reason they have other side effects is because they impact systems in the brain and in the body that impact things like libido, appetite, digestion, and others.”