The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the other problem and we'll get into this in just a second talking about fructose is that they can cause microbiome disruption and so the microbiome disruption I think is one of the biggest issues particularly around the fructose only components that that are leading to some of the pathology that we're seeing inside the studies
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with FR with most of the studies that they are looking at in animal models and humans with fructose they like to feed real high amounts of fructose by itself pure in its pure form and this causes problems in these models because there's a limit to an absorption of fructose and what winds up happening is the leftover fructose gets left in the intestine and then that Can the bacteria present inside the small intestine will start to convert that fructose into different metabolites including things like endotoxin
if you get free fructose in the gut it gets stuck in the gut well what happens if fructose gets stuck in the gut it causes overgrowth of pathogenic bacteria and then you get lipop you get you get lipopolysaccharide you get endotoxin
the negative effects of fructose at the level of the gut and humans is driven by endotoxin and we don't get more antitoxin when we eat fruit in fact I think you could easily make a case that when you eat a blueberry or you're eating a Pon or you're eating orange juice and a toxin which is lipopolysaccharide goes down but the harmful effects of fructose in humans are isolated fructose feeding leading to LPS