Organoids can be exposed to cortisol to mimic human stress responses and analyzed for genomic and epigenomic changes.

“these organoids are little brains in dish that came to be by virtue of taking fiber blasts or other cells so skin cells essentially put into dishes provided four what are called transcription factors these are the four transcription factors that uh yamanaka won the Nobel Prize for identifying that reverts those cells into stem cells and then a few other goodies molecular goodies that then allow them to become neurons in particular then they grow into little mini brains and then as Dr k was explaining are exposed to cortisol at appropriate concentrations to mimic cortisol exposure in the whole person and then from that the genomes of those cells and the epigenomes are analyzed to identify potential targets”