David Sinclair· PhD
In 2008, we has found that the aging brain has derepression of TE, such as LINE-1 elements, in the aging mouse brain, due to movement of SIRT1 (and later SIRT6) to DNA breaks.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
In 2008, we has found that the aging brain has derepression of TE, such as LINE-1 elements, in the aging mouse brain, due to movement of SIRT1 (and later SIRT6) to DNA breaks.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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SIRT1 [a DNA break repair epigenetic regulator] Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging