Lactate can bind to genes and affect gene expression through a process called 'lacation'.

“now we realize they're also lacated so uh we've done some of those experiments here in our lab but the lactate is a predominant uh um metabolite and it can binded to a genes and it it can affect gene expression mean meaning it it can covalently bind mhm A cation methylation lacation that's actually a term and I was it going to compliment you on you're reading the literature CU you can look that up in PubMed and you can see that people are starting to look at lacation of histones by uh raising lactate so it's not through histone acetalation it's direct lactate binding La yeah and it's called lacation yeah”