Ros/rns initiated dna damage can lead to mutations and chromosome damage, potentially inactivating tumor suppressor genes.

“The first way in which these reactive oxygen and nitrogen species can wreak havoc on the cell is by causing damage to your DNA DNA damage is a well-known initiator of mutations as well as chromosome damage when you get a mutation in a gene it can often lead to the gene becoming inactivated and non-functional which then results in an abnormal cell”