David Sinclair· PhD
Reprogramming 3 transcription factors to restore useful vision with youthful features in blind mice
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Reprogramming 3 transcription factors to restore useful vision with youthful features in blind mice
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Reprogramming 3 transcription factors to restore useful vision with youthful features in blind mice
Genetic reprogramming in old mice can restore youthful gene activity patterns, reverse the DNA methylation aging clock, and restore the function and regenerative capacity of the aging retina.
it appears to be within every cell because when we reprogram the animal and currently we're choosing to reprogram the retina and restore eyesight in all mice the cells that get the reprogramming signal from the three genes we put in those cells will survive will regrow will restore their function back to being young again and if a cell next door doesn't get the reprogramming signal it doesn't regenerate so it appears to be intrinsic for each cell
the most impressive i think is work from david sinclair's lab where they they use this optic degeneration model absolutely so uh degeneration of the eye showed that they could reverse that with these reprogramming factors