David Sinclair· PhD
The study shows that Double-Strand Breaks (DSBs) act as a massive distraction event. When DNA breaks, the cell hits the panic button. It recruits proteins (like Sirtuins) from their normal jobs of regulating gene expression, and rush to the break site and repair the damage. This is the Relocalization of Chromatin Modifiers (RCM) hypothesis. The repair crew fixes the break, but this is the critical failure mode, they don't all return to their original posts.