Paul Saladino· MD
there's been some elegant work and I'd like to see it reproduced by Eric Gordon's lab was the first to publish in science that beta hydroxy butyrate functions as a histone deacetylase inhibitor class one and two I believe
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's been some elegant work and I'd like to see it reproduced by Eric Gordon's lab was the first to publish in science that beta hydroxy butyrate functions as a histone deacetylase inhibitor class one and two I believe
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the beta hydroxy butyrate has also been shown to potentially be a histone deacetylase inhibitor have these sort of epigenetic modification capabilities and H the beta hydroxy butyrate can turn Fox o3 on as well
ketones have epigenetic effects there's good evidence that beta hydroxy butyrate is a histone deacetylase class 1 or class 2 inhibitor and affects the transcription of genes
What got us into this field was an observation that we published in “Science” in 2010 showing that beta-hydroxybutyrate, in addition to being a nutrient, as we just discussed, is also a signaling molecule. And what we found at that time was that beta-hydroxybutyrate, which is quite similar to butyrate, butyrate is a byproduct of bacterial fermentation in our gut. Actually, when we eat fibers, these bacteria will digest the fibers into butyrates, and this butyrate actually circulates in many of us as we live. Butyrate was the first known or first identified inhibitor of HDACs, histone deacetylases, which are epigenetic regulators, and so that suggested that maybe beta-hydroxybutyrate might be an endogenous regulator of these HDACs.
class 1 inhibitor of the histone deacetylase
Well, we know like beta-hydroxybutyrate has epigenetic effects as far as activating, you know, histone deacetylase inhibition. And also there's something called beta- hydroxybutyrylation, similar to lag [SP]. So beta-hydroxybutyrate can directly interact with the histone to cause epigenetic modifications