Measuring epigenetic age annually or semi-annually can indicate whether interventions are directionally correct.

“you could every year even every six months do your DNA methyl I'm the Horvath clock and have a look at your rate of change”

“but it's still not going to tell you within a month of what you've just done is working if every year a person had a look at their clock and you could say hey David I'm sort of making this up but David since I saw you last year your genetic clock sped up nine months relative to the 12 months of chronologic aging that you've undergone keep up the good work I can't tie it to what you've done but would I be able to at least directionally say whatever you've done in the last year has been directionally correct versus if you showed up after the following year and it said oh gosh David you've aged two years epigenetically something's not good”

“by contrast we don't have many interventions that allow us to reverse the epigenetic aging rate”