David Sinclair· PhD
Broken chromosomes (or a DNA cut) are a major type of stress that disrupts the epigenome.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Broken chromosomes (or a DNA cut) are a major type of stress that disrupts the epigenome.
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apparently showing for the first time that DNA breaks leave lasting epigenetic scars
DNA breaks leave lasting epigenetic scars.
Natural DNA breaks also disrupt the epigenome
Changes occur genome-wide, not just at breaks