Sirtuins are conserved enzymes across species that act as epigenetic regulators, controlling gene silencing.

“so let's talk more about this for two months we touched on it briefly it's a fascinating family of genes you said there's seven genes in humans they're very conserved across organisms as i've heard you talk about yeast mice fruit flies drosophila well that's fruit flies you know c elegans worms like these this is a this is a very important family of compounds so let's talk a little bit more about what the sirtuins are doing what molecules you found that activate them we'll get into it so let's just tell me more about tartums okay all right so in in yeast where they came from in the first place the name comes from sir two sir two and uh as i mentioned that they're called silent information regulators which is just a fancy name for an enzyme that controls other genes and silences them turns them off okay and so now we would call these epigenetic controllers or epigenetic regulators”