Initiating estrogen therapy at the onset of or before menopause leads to good outcomes, whereas initiating it in the middle to tail end of menopause can lead to bad outcomes.

“He claimed that if they begin estrogen therapy in the middle to tail end of menopause, the outcomes can be quite bad. Whereas if they initiate those estrogen therapies as they enter menopause or even before menopause, then the outcomes can be quite good.”