Peter Attia· MD
They, you know, certainly had some fits and starts, right? They initially were just replacing estrogen. Um, figured out pretty quickly, i.e. within a few years that if you only gave a woman estrogen, you were going to run the risk of endometrial cancer going up because the endometrial lining just continued to get bigger and bigger and bigger and you eventually developed hyperplasia, which presumably became metiplasia and ultimately cancer.