Andrew Huberman· PhD
So you can bypass completely the requirement for testosterone to restore aggressiveness to the mice.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So you can bypass completely the requirement for testosterone to restore aggressiveness to the mice.
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So here are two hormones that are classically thought of as female reproductive hormones, this is what goes up and goes down during the estrous cycle, estrogen and progesterone, and yet, they're playing a very important role in controlling aggression in male mice, and presumably in male humans as well.
It's been shown, and a lot of this is work from your colleague, Nirao Shah, at Stanford, who is one of my former PhD students, that if you castrate a mouse and it loses the ability to fight, not only can you rescue fighting with a testosterone implant, but you can rescue it with an estrogen implant.