Systemic estrogen therapy can be administered through FDA-approved means like patches and gels for hot flashes, bone protection, skin, hair, and nails.

“So um let's talk about all of the different ways in which a woman can get estradiol through an approved tested chemically sound means. Yeah. So um a little bit of nomenclature here right there is systemic estrogen right. So when we're talking about hormone therapy, whether you call it hormone replacement therapy, the new way we talk about it is menopause hormone therapy or if you want to just say hormone therapy is totally fine. We're talking about hormones for your whole body, right? Estrogen for your hot flashes, for your bone protection, um for your skin, hair, and nails, right? That's estrogen. That's systemic estrogen.”