The goal of hormone replacement is to mimic the body's natural production using bioidentical estradiol, progesterone, and testosterone via transdermal application.

“when we talk about you know in the miniverse of what we're trying to replace we all agree that we stick pretty much with estradiol we're just trying to give you back the water you were drinking so I want to be get as close to what your body used to make because that's what the receptor like I'm trying to give you progesterone you know rather than a synthetic and for your androgens we pretty much just do testosterone and we do a transdermal again because the oral can be hepatotoxic unless it's uno8 which isn't um available in the US”