Moderate to high-intensity treadmill exercise in early-stage Parkinson's disease patients improved dopamine receptor sensitivity.

“so like they're basically using it better right you know the little they have it's better at it you know right more efficient yeah so that was another thing that we had seen which is actually changes in dopamine receptors right so the idea was that we'd taken patients who had not been on anything and um essentially no meds anyway and you know were really recently diagnosed and then putting them on on a treadmill and i would argue that although the treadmill again so intensity in two ways one obviously getting their heart rate up but they were actually also getting a lot of feedback on gate and balance again correcting constantly correcting going up on speed so they had to become having like a personal trainer seems to kind of it was important yeah they were getting tons of feedback and by going up on speeds now you're having to work harder to make sure you're accurate so again you're in the zone if you will um but in any event yeah so we were able to show that we saw changes in in domain receptor levels but the idea being that the amount of domain you have with a better receptor expression you're becoming more efficient and that was uh duplicating what we saw in the animal model”

“eight weeks of intensive treadmill training three times per week can increase the expression of dopamine receptors in the basal ganglia by 80 to 90 percent in parkinson's disease patients”