The release of IL-6, conventionally thought a simple marker of inflammation, actually plays a crucial role in the insulin sensitizing effects of exercise.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The release of IL-6, conventionally thought a simple marker of inflammation, actually plays a crucial role in the insulin sensitizing effects of exercise.
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We talk about the role of IL-6 as a myokine and necessary for the insulin-sensitizing effects of exercise.
So if you block IL-6 in a row that exercises, you block all the beneficial metabolic effects.
IL6, which we think of it as mostly inflammatory cytokine in the context of sickness, is a myokine in the context of exercise. We know in the context of exercise that IL6 plays a key role in exercise’s ability to induce insulin sensitivity.