Complete liver glycogen depletion leads to a shutdown of physical activity, whereas muscle glycogen depletion is less absolute.

“but when your liver getss low you're going to be shut down and that's the case of if you've ever been to like a marathon and you've seen people run like 25 and a half miles and then they just like Bonk they go into like baby deer walking stance and then they collapse and you're like how are you mentally weak like you ran 26 miles and you can't run the last point it ain't mentally weak it is if your liver is done it's going to stop you because there's no more backup reserves muscle you can get away with you can push through it liver will not let you go any farther”

“the way in which you would deplete muscle glycogen would be through more — intensive exercise”

“it's almost impossible to completely deplete the glycogen”