Osteocalcin release in response to load-bearing exercise signals movement to the brain and updates neural circuitry.

“That's a signal to release osteocalcin, and we know that signal occurs. That is directly reflective of the fact that the body was moving and moving in particular ways.”

“And we talked about how to leverage exercise, in particular, load bearing exercise in order to evoke the release of hormones like osteocalcin which can travel from your bones to your brain and enhance your ability to learn.”

“what this means is that any exercise program that's designed not just to benefit our body but also our brain health and performance should do something to load the skeleton in some sort of impactful way that causes the release of osteocalcin”

“exercise improves brain health in the long term yes through the deployment of things like bdnf yes through the deployment of things like osteocalcin and on and on but it also does so by improving your sleep”

“And this idea that the body is constantly signaling to the brain about the status of the body and the varying needs of the brain to update its brain circuitry is a really attractive idea that fits entirely with the biology of exercise, osteocalin, and hippocample function.”