Exercise, particularly high-intensity training, can increase monocarboxylate transporters (MCT transporters) to facilitate lactate removal from the muscle.

“yes we've done this in animals and we've done it in uh looking at trained and untrained people and we can see an increase in the abundance of the MCTS now that that helps two ways because getting lactate into the mitochondrial Network requires an MCT so we were bold enough to look at the mitochondria and find MCTS so people think well it's just on the cell me membrane and it's good for E uh export and that's true but uh in um oxidative muscle fibers with a abundance of Transporters many of them are in the mitochondria so the lactate will move into the mitochondria as well as can be exported”

“the MCT transporter on the muscle cell must play a significant role in determining the relationship between intracellular lactate and intop plasma lactate and I I you know it would be in an athlete's best interest through training to increase the density of those because the more you can get lactate out of the cell the more presumably you're going to get the hydrogen with it out of the cell we probably have a greater capacity to buffer lactate pardon me we probably have a a better capacity to buffer acid in the plasma because we have the respiratory drive to get uh to to adjust bicarb than we do in the cell where it's you know that hydrogen is really poisonous”

“And, as well, you can double the amount of lactate transporters. And so, you can really upregulate the ability to do this process we call the lactate shuttle.”

“A major adaptation there is an increase in monocarboxylate transporters, MCT transporters, to help get the lactate out of the muscle.”