The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the muscles producing lactate is terrific but the asites producing lactate for the neurons to feed on is also terrific because lactate can be used as a fuel and it triggers all these Downstream or subsequent mechanisms including bdnf so basically what we're talking about is the lots and lots of ways that exercise improves brain health in the longterm
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that lactate also is is it's it's important for neurotransmitter synthesis you're you're um making glutamate the major excitatory neurotransmitter of the brain it's it's important for making precursors to that norepinephrine I mean these are all been shown in human studies also animal studies
that lactate also is it's it's important for neurotransmitter synthesis you're you're um making glutamate the major excitatory neurotransmitter in the brain it's it's important for making precursors to that norepinephrine I mean these are all been shown in human studies also animal studies
Resistance exercise results in high lactate which crosses the blood-brain barrier and induces BDNF to improve learning/memory.
Vigorous exercise causes muscles to produce lactate - which crosses the blood-brain barrier and is a messenger for the brain to produce neurotrophic factors like BDNF.
BDNF, dubbed "Miracle-Gro for the brain," enhances neurogenesis and neuroplasticity, forming and rewiring the connections between neurons.
I advocate for high-intensity exercise in part due to its brain benefits, which primarily stem from lactate. Lactate fuels the brain & muscles (not causing fatigue or soreness, as once thought) and activates growth factors and neurotransmitters.
Lactate generated during intense exercise signals to the brain to make BDNF
And looking at the studies on lactate and, you know, even infusing lactate into humans, it increases BDNF, just infusing it.
So lactate actually is a signaling molecule. It has been shown to activate brain-derived neurotrophic factor at the blood-brain barrier. It activates it. It also gets into other tissues, including the brain, through this MCT transporter. And it's used for neurotransmitter synthesis, norepinephrine uses lactate serotonin dopamine. It's used for energy instead of neurons. It's a very efficient source of energy.
And I feel amazing after, I feel sharp, you know, lactate is important again for neurotransmitter synthesis and stuff. And so, you know, it's the feeling that I feel, mood as well.
when you produce lactate it's getting into circulation and it can cross the bloodb brain barrier there are lactate Transporters MCT Transporters on the bloodb brain barrier and it can you know cross the blood brain barrier and get into the brain where it then acts as a signal and it triggers a variety of beneficial adaptations
brain Drive neurotropic factor is important to get those learning and memory benefits from exercise and again lactate is a key signaling molecule that increases brain dve neurotropic Factor
lactate itself has been shown to be responsible for increasing braind derived neurotropic Factor both in the plasma this is in human studies — humans at exercise lactate correlates with the bdnf activation in plasma bdnf can cross over the bloodb brain barrier but also animal studies showing that it directly increases brain derived neurotrophy factor in the brain
animal Studies have found that exercise increases lactate which crosses the bloodb brain barrier gets into the brain and increases mitochondrial biogenesis in the hippocampus um and neurons in the hippocampus so mitochondria in neurons in the hippocampus are being increased I I don't know why that mechanism wouldn't be conserved in humans
lactate is generated from your exercising muscles when you're forcing them to work hard this isn't just going on a brisk walk this is really getting your heart rate up swe sweating getting flush in the face
one of those is that it signals to the brain to make something called brain Drive neurotrophy factor or bdnf and what this is is a growth factor that is involved increasing new neurons inside the hippocampus
lactate one mechanism because lactate has been shown to cross over to the bloodb brain barrier and in the brain activate brain Drive neurotropic Factor
A lot of that has to do with the fact that lactate is produced when you exercise intensely. When you work really hard, you're forcing your cells to make energy in a way that is producing lactate as a metabolic byproduct. Turns out it's not just a metabolic byproduct. In fact, lactate is a very important substrate not only to make energy, it's used, it's actually energetically more favorable to use lactate than glucose to make energy.
Um, lactate also shuttled to other parts of the body and most I think importantly the brain where it acts as a signaling molecule. In other words, it's a way for your muscles to communicate with your body like your brain and say, "Hey, I'm working hard here. We got to like respond to this work."