The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
every time you do that run, what you're doing is you're building up mitochondrial density. It's not so much about mitochondrial oxidation and respiration. You're building up mitochondrial density. You're actually increasing the amount of ATP that you can create for a given about of effort. You're becoming more efficient. Okay? You're burning less fuel overall doing the same thing. That's really what these long slow distance or long bouts of effort are really all about.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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When you go out for a run that's 30 minutes, you are building the capacity to repeat that performance the next time, while being more efficient, actually burning less fuel. That might seem a little bit counterintuitive, but every time you do that run, what you're doing is you're building up mitochondrial density. It's not so much about mitochondrial oxidation and respiration, you're building up mitochondrial density. You're actually increasing the amount of ATP that you can create for a given bout of effort. You're becoming more efficient. You're burning less fuel overall, doing the same thing.