The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The enzyme that's involved here is something called pyruvate kinase. You don't need to know about pyruvate kinase but what you do need to know is that it ends A-S-E which means it's an enzyme and pyruvate kinase is essentially a rate limiting step. It's a critical step that you can't bypass if you want muscles to contract and it's very temperature sensitive.
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And I think this is a much underexplored or at least a much under discussed aspect of so-called muscular failure or the failure of one to continue to endure
There's an enzyme called pyruvate kinase, which is critical to muscle contractions and pyruvate kinase can only function in a very narrow range of temperatures. If that temperature gets too hot, meaning if the muscle heats up locally, whether or not by running or cycling or swimming or weightlifting, the ability for that muscle to continue to contract is reduced and eventually is short circuited completely.
When muscle heats up, enzymes start getting disrupted, and ATP and muscles can't work so well and those muscles can't contract. The enzyme that's involved here is something called pyruvate kinase. And pyruvate kinase is essentially a rate-limiting step. It's a critical step that you can't bypass if you want muscles to contract. And it's very temperature-sensitive.