Persistent exercise chronically activates mTOR, which may be beneficial due to signaling through a different process than nutrient-induced mTOR activation.

“And so now we're beginning to understand that mechanical stress from exercise is routed through a different process, the nutrient stimulation of protein synthesis. So, you know, maybe that's the underpinning mechanism why a lot of people talk about, you know, restricting protein and not wanting to turn on the overly or overly turn on the anabolic side of things, you know, because uncontrolled growth and, well, you know, cell level, that's cancer. But as I point out to people, you know, persistent exercise also activates mTOR on an almost chronic basis if you exercise every day. And now we're like, "Well, actually, it's signaling through a different process." So maybe that's why it's beneficial.”