The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it is also why you don't need to worry about doing things to quote unquote um reduce lactate in the muscle after exercise or to clear lactate or any of those things you may still want to do those activities but not for that reason
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it's also can be then used directly back in the muscle because as soon as you bring in enough oxygen and you can take that hydrogen back off of it you've now turned it right back into pyu and you can run it through this whole cycle as fuel that I'm about to do you can actually actually ship it out of the exercising muscle and ship it into a non-exercising muscle and then go backwards and make glucose
a dog muscle made to contract with adrenaline or otherwise will release p ruaan lactate which will recirculate to the liver and become glucose so that's a way to support Supply blood glucose uh during exercise
Exercise causes your muscles to produce energy in the form of lactate which, interestingly, gets hungrily used by tissues other than the muscles (muscle → heart, muscle → brain, muscle → liver). This is called the "lactate shuttle."
And we use that word "preferred." That's very interesting because we've given lactate to men during exercise and it is preferred over glucose. In muscle and in heart. Yeah. And also in brain.
He is the pioneer of research that he proposed back in the early '80s that has to do with lactate that is generated from muscle during exercise and how that lactate is used by a variety of different tissues in the body to produce energy.
because if you don't have enough oxygen there, the lactate you produce isn't gonna get used. It's gonna... [George]: It's gonna pile up.
So, you know, the lactate shuttle theory or lactate, you know, many of us, if you look back at your textbooks, you'll learn that lactate was this metabolic waste product, end product, and it's just a metabolite like anything else. And it can be an extremely valuable fuel. And we know that...and there's elegant studies, including from Dr. Brooks and others, to show that, you know, first of all, skeletal muscle can produce lactate under fully aerobic conditions. So there's always some lactate production happening. And certainly, during more intensive exercise where we produce lactate inside the muscles, it can be released from active skeletal muscle, it can circulate to other places like the heart, like the liver, like the brain, but certainly in heart. Heart can be a big consumer of lactate, and so it takes up that lactate, can convert it back to glucose, and then utilize it during exercise. And so this is the idea of cell-to-cell or inter-organ lactate exchange, and I think that's very well established now.
the anerobic pathway can lead to the production of lactate especially when the intensity of exercise surpasses the point at which the oxygen intake can keep up with the energy demand and and so this is sometimes often referred to as the lactate threshold as we talked about for a long time lactate was considered primarily as a waste product contributing to muscle fatigue and you know this has of course been completely revers Recent research Arch has you know totally changed this understanding lactate generated in muscle tissue is transported not only back into muscle and into mitochondria to be used as an energy source but it also when it starts to accumulate at higher levels travels systemically into circulation and gets transported to other tissues like the heart the liver the
Recent research Arch has you know totally changed this understanding um lactate generated in muscle tissue is transported not only back into muscle and into mitochondria to be used as an energy source but it also when it starts to accumulate at higher levels travels systemically into circulation and gets transported to other tissues like the heart the liver the brain where it's used for energy um it's also used as a signaling molecule so this is known as the lactate shuttle and was pioneered by Dr George Brooks who has really changed the field
it's not necessarily a byproduct anymore it's an active metabolite that is not only an energy source for mitochondria it's also a signaling molecule so in other words it's a way for your muscles to communicate with your muscles and P proteins in your muscles it's also a way for your muscles to communicate with other organs like the brain and the heart and the liver and your kidneys and so that lactate actually is a signaling molecule to the muscle cells the glucose Transporters in the muscle then come up they're it's called translocation they come up to the cell surface of the muscle and they're open and primed and ready to take in lot of glucose and lactate is really key in that process