Lowering LDL cholesterol is associated with a reduced risk of major vascular events in a linear or logarithmic relationship.

“you could look at ezetimibe trials and fibrates and niacin and cetp and statins and diet and bile acids equestrians and ileal bypass and our favorite the pcsk9 inhibitors which i'm sure we'll talk about a little bit today and so you could say hey look it's very clear it's linear and this is what dave said earlier it's logarithmic and linear except it's not because this completely ignores the context which is that if 88 of people are diseased sure you could have this relationship but try and do this or show me what this looks like with lean mass hyper responders with people who are fundamentally metabolically healthy that is what western medicine misses not surprisingly because western medicine knows nothing about nutrition and most doctors are fat”