Calorie restriction can improve physiology and lead to ketosis, but may not result in stable blood sugars and can lead to long-term nutrient inadequacy.

“could even be in ketosis with a diet that was entirely made of Twinkies if it was calorie restricted so we can get improvements in physiology with a calorie restricted diet but what we're not gonna get is stable blood sugars and we know that these median amplitude who Coast excursions postprandial e meaning how high the blood sugar ramps up after you eat can affect the endothelium and many other vascular markers in the negative way and long-term nutrient adequacy is not going to be able to be achieved by Twinkie diets”