David Sinclair· PhD
Weight loss was associated with mTOR activation and decreased autophagy gene expression (in gut lining biopsies), not in the direction of longevity...
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
Weight loss was associated with mTOR activation and decreased autophagy gene expression (in gut lining biopsies), not in the direction of longevity...
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
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Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.