Rhonda Patrick· PhD
We know with fasting and the ketogenic diet that you can increase permeability to the blood-brain barrier.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
We know with fasting and the ketogenic diet that you can increase permeability to the blood-brain barrier.
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So maybe if you're fasting maybe there's just less stuff in your blood, there's competition of things getting through and your blood's sort of clear and you introduce the drug and you get more rapid transport because there's co-transporters and other things or things that might be in their diet that may be impeding transport, there's multiple independent lines of evidence to suggest that being in a state of ketosis can help better transport things across
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.