While fasting can induce autophagy by consuming sick cells, the long-term effects and potential detriment of continuous fasting on autophagy rates are not well-studied.

“but for how long I don't I don't think any study has has looked at basically at one point does fasting induced autophagy become become detrimental all I've seen is that yes sure in the first six hours of fasting or the autophagy rates are greatly increased but what happens afterwards what happens if you if you actually fast continuously I don't know of a study that looked even at the everyday for six hours continuous fasting effect on autophagy my guess is that at some point the body will down regulate that response simply to preserve tissue right and keep your life for longer”

“but for how long? I don't I don't think any study has has looked at basically at one point does fasting induced autophagy become become detrimental. All I've seen is that yes, sure in the first six hours of fasting, the autophagy rates are greatly increased. But what happens afterwards? What happens if you if you actually fast continuously? I don't know of a study that looked even at the uh every day for six hours continuous fasting effect on autophagy.”

“Do we really have enough data to say that the the risk, you know, is outweighed by the benefit in terms of autophagy? I don't I'm not convinced that we do.”

“do we know if autophagy is impaired in older folks with fasting”

“I don't know that I necessarily I think autophagy is as good as the the markers that we are sensitive assays that we have to measure it and I don't know that it's settled with respect to how long I personally think there's probably even in between meals there's some amount of autophagy a topologies are happening in us it is yeah it's not like we're not but is it clinically significant right or more so than say exercise would induce yeah no right exercise like no like extras nothing like the exercise is like that's my point like how long would you need to fast to to get the benefits how long would you need to fast to get the benefits of an amazing workout and what my thinking is right probably a long time”