Paul Saladino· MD
I think people need to be careful with one meal a day because I think that if you eat too infrequently or we compress the feeding window too much you can get hormonal things
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
I think people need to be careful with one meal a day because I think that if you eat too infrequently or we compress the feeding window too much you can get hormonal things
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I don't think that calorie restriction and I don't think that smaller and smaller feeding windows is the way that humans optimally lose weight from a hormonal perspective
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.