Paul Saladino· MD
but when you eat may be just as important perhaps even more important than what we put in our mouths
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
but when you eat may be just as important perhaps even more important than what we put in our mouths
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what we are doing in rats wasn't really caloric restriction we're doing intermittent fasting because in rodents we would bring the food in the morning they were hungry right they would eat all the food you know the 60% whatever we gave to it libido and they were fasting for 23 hours
maybe it's the timing that's the important thing the fact that they're fasting for 23 hours a day or 23 and a half hours today maybe that more than the total consumption or as much as the total consumption is doing it
So, it turns out that most, perhaps all of the rodent studies with rats and mice of calorie restriction are also intermittent fasting studies. And the reason is the way they did the studies, they take 20 animals, they divide them into two groups, you, over a period of a week or two, determine how many food pellets each animal eats each day. Sorry. You do that before you divide them into two groups. So, essentially, you get, for each animal, their daily calorie intake. And then, you divide them into two groups. In the calorie restricted group, you give, say, 20% fewer pellets than they would have normally eaten each day. And you give it to them all at once. It turns out, when that's done, because they're calorie is restricted, they eat all of their food in a short time period, like within four to six hours. So, they're actually fasting for up to 20 hours.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.