Paul Saladino· MD
Folate and choline both support methylation and one of the endpoints you would look at is homocysteine which increases when you don't have adequate methylation in the fasting state
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Folate and choline both support methylation and one of the endpoints you would look at is homocysteine which increases when you don't have adequate methylation in the fasting state
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
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Time-restricted eating produces fat loss independent of total calories.
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One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.