get into some changes in my views around fasting and protein consumption
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
get into some changes in my views around fasting and protein consumption
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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in the middle of 2014 is when I started to experiment with fasting
give you another example right like how much emphasis did I used to place on fasting how much emphasis do I place on fasting today totally different
I think I'm you know this is one of those things where I'm going to reserve the right to completely change my mind right if there's some if there's if I if I had some biomarker that could convince me that a seven day fast even once a year had a meaningful rewrite on some negative processes in my body I mean I would I would happily make that sacrifice again but in the absence of knowing that I I just I don't you know the cost is a bit high right now
I'm not and I mean I think there are several reasons I'm not but truthfully um perhaps one of the most uh logistically relevant ones is just I don't travel anymore and I used to only do my long fasts when I was traveling when I was away from home and it was just so much easier to be fasting when I was in New York than uh being at the time in San Diego but now I never travel so it would mean that if I wanted to do long fast I'd be doing them at home and um you know I just don't I just don't feel like doing it and I don't have a better answer than that
I would really need to see something incredibly compelling in a higher order model um maybe in a dog model or something like that you know again like this is a great example of where that's such a I I think I think companion dogs are such a great um model to study things that that you know cuz again I think most people find binary fasting far easier than caloric restriction and there's already a lot of controversy around caloric restriction I have an entire chapter on this in outlive where I talk about um the the Wisconsin niia Mouse uh uh sorry um the monkey studies but you know for most people like if I said oh you just got to reduce calories by 25% for for the rest of your life and you're going to live longer most people would say I don't want to live longer that's torture
I don't know I would really need to see something incredibly compelling in a higher order model um maybe in a dog model or something like that you know again like this is a great example of where that's such a I I think I think companion dogs are such a great um model to study things that that you know because again
first and foremost what we see the most is questions around long-term fasting and its potential benefits on longevity so not fasting to kind of count calories anything of that nature but more so how you think about quotee unquote long-term fasting as it relates to longevity
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.