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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Is fasting beneficial for longevity? — Whalespan

Content›Video›Is fasting beneficial for lo…

Is fasting beneficial for longevity?

Peter Attia12m · 2024-05-08

Claims Made

16

Claims Supported

4

Support Rate

25%

Support rate

4 of 16 claims supported

4 supported12 partial / not

Claims from this content

13

◐Partially SupportedPeter Attia would consider resuming long-term fasting if presented with compelling evidence from higher-order models like dog studies.◐Partially SupportedLong-term benefits of fasting for longevity are difficult to study with definitive clinical trials.✕Not SupportedPeter Attia stopped fasting due to difficulty regaining lean muscle mass, losing approximately 20 lbs of muscle over three years.◐Partially SupportedFasting for approximately five days may produce cellular changes beneficial for disease prevention.Partially Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Fasting can negatively impact thyroid and androgen function, and transiently improve standard biomarkers like glucose and insulin.

◐Partially SupportedPeriodic prolonged fasting may share common pathways with caloric restriction, such as a shift in metabolism towards beta-oxidation and potentially a ketogenic mode.

◐Partially SupportedPeter Attia previously practiced and recommended quarterly 7-10 day water-only fasts supplemented by monthly 3-day fasts, acknowledging this protocol was self-invented without supporting data.

◐Partially SupportedFasting and caloric restriction are interventions that have been shown to extend life across all model systems of eukaryotes.

✓Well SupportedCaloric restriction is less sustainable than intermittent fasting for most people in Western countries.

◐Partially SupportedFasting can be a tool for weight loss and caloric restriction.

◐Partially SupportedReducing calories by 25% for life is perceived by most people as undesirable.

?Limited ResearchDetermining the long-term efficacy of fasting for longevity is difficult due to the lack of dispositive clinical trials and the need for better biomarkers for the hallmarks of aging.

◐Partially SupportedPeter Attia practices time-restricted eating for caloric restriction and managing total caloric intake.