Peter Attia· MD
This is, IMO, the problem with not being able to measure autophagy, which is my primary interest today.
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
This is, IMO, the problem with not being able to measure autophagy, which is my primary interest today.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
i wish i had a biomarker to point to i wish i had some way of measuring whether this is the right thing to do or if there's a or if you know eight four eight four eight four right there's a symmetry to eight five because you'll get through exactly four cycles a year maybe i do eight five eight five eight five eight five um but it really frustrates me that we don't have a biomarker for this yeah or or age in general yeah for age in general so let's talk a little bit about that so what is what does that look like i mean when i had eileen white on the podcast uh gosh it's been maybe a year and a half now we had a really interesting discussion about why we don't even have biomarkers for autophagy i mean something that is so important and we can't measure it and this was important in the context of people who choose to calorically restrict or fast
why is this fuzzy well I think it's fuzzy because we don't have the bio in many ways this suffers the same problem rap ay suffers in terms of getting into much more dispositive clinical trials which is we're clearly ever going to do the experiment that asks people to undergo different fasting protocols for the entirety of their life to determine if indeed they live longer so we're going to have to come up with better proxies meaningful biomarkers of the Hallmarks of aging
the thing we couldn't measure which was what was actually happening to those Hallmarks of Aging right were we improving at the cellular level things like syence autophagy all of those things well guess what we can't measure those things so we don't know
the thing we couldn't measure which was what was actually happening to those Hallmarks of Aging right were we improving at the cellular level things like syence autophagy all of those things well guess what we can't measure those things so we don't know
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.