David Sinclair· PhD
In mice, there is a non-linear relationship between decreased caloric intake and lifespan extension, which also depends on genetic background. The same is probably true for humans...
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In mice, there is a non-linear relationship between decreased caloric intake and lifespan extension, which also depends on genetic background. The same is probably true for humans...
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even in mice where we can control everything else if you look across genotypes you get different results from the same diet and the effect of caloric restriction on lifespan
Time-restricted eating produces fat loss independent of total calories.
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One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.