Paul Saladino· MD
so until we know more I would not you know try to increase autophagy further by by fasting
Loading…
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
so until we know more I would not you know try to increase autophagy further by by fasting
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
So we don't know enough about the process to be stimulating it beyond the baseline which is what happening while we're sleeping right and also between meals. I mean I know studies have shown that you do have you do trigger autophagy um if you basically have at least three or four hours between meals. So I don't know of a of a good reason or argument scientific that we should be increasing it beyond that because you know we trigger a lot of catabolic processes that um you know at some point may get out of hand.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.