Peter Attia· MD
if I measure my IGF level before fast right before a fast it might be 180 to 200 and right after the fast it's eighty or ninety and six weeks later it's maybe one forty one fifty
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if I measure my IGF level before fast right before a fast it might be 180 to 200 and right after the fast it's eighty or ninety and six weeks later it's maybe one forty one fifty
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about once a quarter I fast for a week with just water only and it has a profound impact on my IGF level
my IGF-1 went down to 69, at the end, I was at 69.
But if you look at some of the work from, for example, Valter Longo, when they've looked at a 48-hour fast and the drop in IGF-1 levels, it goes to about 50%. And in humans, you know, looking at what it takes to drop IGF-1 to 50%, it's anywhere between 5 to 7 days.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.