David Sinclair· PhD
I take 800 milligrams at night. - Okay, and you take that at night because? - Well, because doctors tell me that it's a good time simulate a fast. I take it with my dinner, just after.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I take 800 milligrams at night. - Okay, and you take that at night because? - Well, because doctors tell me that it's a good time simulate a fast. I take it with my dinner, just after.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Well, because doctors tell me that it's a good time to sim simulate a fast.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.