Training while fasted increases gene activity related to fatty acid metabolism in muscle and fat tissue over the long term.

“But regardless, there was a variety of metabolic adaptations that, for example, mitochondrial fatty acid oxidation was enhanced, mitochondrial biogenesis. These things were somewhat blunted in people that exercised in a fed state. Whereas, if they had done it in a fasted state, these adaptations were occurring even throughout the day when the people were not exercising.”

“You know, if you eat before, you know, you go for a run or something, that, you know, a lot of the mitochondrial adaptations can be blunted somewhat. And, of course, a lot of those studies are using high refined carbohydrate like some toast with jam, you know, where...”

“If you're doing more of an endurance type of training, as long as it's less than an hour, you can actually enhance some of the metabolic adaptations. And maybe that's the question you're asking. If you're wanting to increase more things like autophagy, so this is what a lot of people are doing. Um, they're they're aiming to increase autophagy, and that's why they're intermittent fasting among other reasons, but autophagy is when you're in in that fasted state.”