The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Also showing that people of regular weight, like me, can benefit from fasting, there's a number of studies there. But what's really interesting is that certain diseases, type one diabetes, multiple sclerosis even cancer, those diseases seem to also benefit from fasting, including when you combine chemotherapy with fasting, you get this double benefit for many types of cancers.
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if you fast for 48 um to 72 hours before you get chemotherapy there are many studies showing that there is improved outcomes and reduction in chemo um side effects and so that's probably through autophagy
I mean certainly there's evidence to suggest that fast and coupled with chemotherapy can increase the efficacy of chemotherapy I mean this has been now actually demonstrated Valter Longo has talked about this quite a bit but you know Dom D'Agostino's been talking about this for at least five years now
we contrast that with an abundant body of literature that suggests that when you combine fasting which is a potent inducer of at otha G with chemotherapy for example you enhance its efficacy
Do you think that the reason for that is that the chemotherapy itself maybe once you you're rendering the cells more sensitive to chemotherapy and also potentially generating a more durable immune response
So there there are a couple of clinical trials that have shown that water only fasting for at least 24 hours reduces the side effects during chemo.
But it's important to understand that when you reduce the side effects of chemo, it allows you to typically use more chemo, right? So so you can tolerate it more and many times a patient is unable due to the side effects to go through the the completion of the chemotherapy.
Fasting-mimicking diet combined with chemo caused tumors to shrink 50% more than in mice that received chemo alone.
Animal evidence suggests the fasting should be during and shortly after chemo… not just beforehand.
Cancer patients fasting up to 72 hrs before chemo lowered damage to immune cells & reduced biomarkers of cancer.
Cancer patients fasting up to 72 hrs before chemo lowered damage to immune cells & reduced biomarkers of cancer.
They now continue the fast through the dose of chemo, not just beforehand.
The actual one with fasting, where the cancer patients fasted either before or after the chemo treatment, and I thought it was very interesting that you found, maybe you can talk about it, but you found that their normal cells were more resistant to the stresses of chemo, whereas the cancer cells were more sensitized to that.
So one is I think you've shown without a doubt, in both animals and also in some preliminary work in humans, that the fasting or the fasting-mimicking diet can sensitize cancer cells to the standard of care, whether that's chemo, radiation, whatever, you know, death, while still protecting the normal cells, which are upregulating all sorts of protective pathways, as you mentioned.
This is why, in mice, we see cancer-free survival, meaning myself free of cancer only when we combine the starvation or the fasting-mimicking diets with the chemotherapy. We almost never see it when we use each one alone, right?
he was able to show that with this intermittent short-term fasting, even in humans, he could not only improve the efficacy of chemotherapy but prevents some of the side effects.
So, we see that you need to have in most cases the powerful target intervention with the fasting. So like fasting and chemo, fasting and kinase inhibitors, fasting and immunotherapy for example.
he's published a couple of pilot studies showing that a 48 hour water fast is safe and not only is it safe there seems to be a beneficial effect on sensitizing cancer cells to death and protecting normal cells from the toxicity of chemotherapy and/or radiation
And it can enhance the killing of cancer cells by chemotherapy drugs and radiation.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.