Nrf2 can be activated by heat stress, cold stress, exercise, and fasting, increasing glutathione levels.

“nrf2 can be activated by all sorts of things in the human body it's part of a process of you know it's triggers the production of more glutathione which ours is our endogenous antioxidant people often misunderstand the fact that so forth aim is not beneficial so for vain is a toxin there is a concept of hormesis whereby a small amount of a toxin can trigger the entry production of increased amounts of glutathione in the human body but so forth pain is not directly beneficial to humans in fact it's directly harmful and I'll tell you why in one second but so foreigner fame is doing something in the liver by triggering the nrf2 pathway that we can do on our own heat stress cold stress exercise fasting these all increase our glutathione levels and cause oxidative stress we don't need so for thing to have adequate or optimal levels of glutathione so it's a redundant effect”