The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you calorically restricted them they lived longer if you overexpress sir two they lived longer if you did both they lived even longer it was additive again further suggesting that overexpression of sir2 and caloric restriction independently and separately extended lifespan
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
someone else in the same lab took a different strain of yeast and calorically restricted them and they also lived longer
there is no evidence that caloric restriction and cerin operate through the same pathway and in that sense I think there's there's relatively uniform agreement that caloric restriction extends life across the model systems we discussed
if you put and met cable line um a student who was in the lab when i was over at mit he put an extra copy of the sur2 gene into yeast and they lived 30 longer and later we figured out that that was mimicking caloric restriction
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.